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Symbol
Name
ID 		Myc
myelocytomatosis oncogene
MGI:97250
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Neutropenia
Decreased proportion of CD4-positive helper T cells
Leukocytosis
Leukopenia
Acute promyelocytic leukemia
Stomatitis
Abnormal lymph node morphology
Lymphadenopathy
Abnormality of the spleen
Immunodeficiency
Chronic infection
Disease(s) Associated with MYC
acute promyelocytic leukemia
Burkitt lymphoma

Mouse Phenotypes
immune system phenotype
increased B cell apoptosis
decreased B cell proliferation
increased B cell proliferation
decreased T cell proliferation
enlarged thymus
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal lymphopoiesis
abnormal T cell receptor beta chain V(D)J recombination
increased B cell number
increased pre-B cell number
decreased NK T cell number
decreased memory T cell number
decreased T cell number
increased lymphocyte cell number
increased macrophage cell number
increased leukocyte cell number
spleen hypoplasia
abnormal NK cell physiology
abnormal immune system organ morphology
enlarged lymph nodes
lymph node hypoplasia
small lymphoid organs
lymphoid hypoplasia
kidney inflammation
Availability Mouse Genotype
Myctm1.1(Nmyc1)Fwa/Myctm1.1(Nmyc1)Fwa *
Myctm1.1Cksn/Myctm1.1Cksn *
Myctm1Lbox/Myctm1Lbox
Tg(HBVX*,-Myc)#Skp/Tg(HBVX*,-Myc)#Skp
Myctm1Atp/Myc+ *
Myctm1Atp/Myctm2.1Atp *
Myctm1Lbox/Myc+
Myctm2.1Atp/Myc+
Myctm3(Tcrb)Fwa/Myc+
Tg(HBB-Myc)#Cos/0
Tg(IghMyc)22Bri/0
Tg(Pklr-Myc)73Ak/0
Tg(IghMyc)22Bri/?
Myctm2.1Atp/Myctm2.1Atp
Tg(Mx1-cre)1Cgn/0  (conditional)		 *
Myctm2Fwa/Myctm2Fwa
Cd19tm1(cre)Cgn/Cd19+  (conditional)
Myctm1Atp/Myctm2.1Atp
Tg(Mx1-cre)1Cgn/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory